Post-doctoral fellow in Organic Chemistry
Lund University
The subject of the position is organic chemistry at the interface with chemical biology. The research concerns the development of a modular chemical platform for targeted protein degradation in bacteria (BacPROTACs) as a new strategy against antimicrobial resistance (AMR). Bifunctional molecules are designed and synthesised to recruit endogenous bacterial proteolytic machinery, such as the ClpC:ClpP system, in order to selectively degrade essential proteins in drug-resistant Staphylococcus aureus , rather than inhibiting them.
View position